Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
根据世界黄金协会(World Gold Council)的数据，自2008年以来全球黄金供应每年都增长，这一增长在去年陷入停滞。作为世界最大的黄金生产国，去年中国的黄金供应创纪录地下降9%，这是自1980年来中国的黄金产出第二次下降。
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Boston Consulting Group could also be poised to make a change given its managing partner, Richard Lesser, is due to come to the end of his second term in October. His future is unclear, however, as the firm declined to comment on its election process or how many terms its leader can serve.
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Rossello also has pledged to work closely with a federal control board that U.S. Congress created last year to oversee Puerto Rico’s finances, and he has said he supports negotiations with creditors to help restructure a nearly $70 billion public debt.
Gitanjali said she wanted to further refine the device so it could eventually go on the market.
Trends and targets in antiviral phototherapy
Among the top 50 richest women in the world, entrepreneurs from the Chinese mainland account for 56%.
Yes, they hedge on the timing but the ticking time bombs are loud, close. And 'the precious-metals crash, starting in April of 2013, was the first warning of what is coming globally.'
Xu said at a press conference that by 10:20 am, 97 bodies have been retrieved.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Inside Obama's Chicago campaign headquarters, staffers erupted into cheers and high fives as state after state was called for the president。
ACE2 as a potential therapeutic target for pandemic COVID-19
The memes included jokes about pedophilia, child abuse, sexual assault, and the Holocaust.
Diagnostic technologies for COVID-19: a review
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
1. “Timbuktu”(Abderrahmane Sissako)
6.Jack Shephard Almost Died in the First Episode
The Microsoft founder's net worth is $86 billion, up from $75 billion last year.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
“An employee stormed out in the middle of a meeting, without explanation.”
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
7.You Haven't Gotten a Raise in the Last Two Years
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
The only things in the way are his staff, Republicans in Congress and the limits of his power. And those are important. Campaign promises of 45 per cent tariffs on Chinese goods have turned into investigations into Beijing’s intellectual property regime.
These collaborations signal a moment where the cradle of innovation and the arbiters of fashion are finally embracing one another, says L2 research director Colin Gilbert. Style is not the only missing piece to the wearable puzzle, but it’s something to look forward to, Gilbert says. More than half of the report’s respondents want devices that feel more like jewelry while 62 percent would like more than wrist-worn devices.
Influenza neuraminidase: A druggable target for natural products
BuzzFeed News defined “fake news” as news that was verifiably “100 percent false” and drawn from a list of 96 websites purposely created to disseminate false information.
Welcome, and before we begin – please accept our apologies. Your four-hour nightmare wait at passport control should not be taken as a symptom of Britain's contempt for foreigners. It is merely a symptom of a woeful lack of spending on a key aspect of travel infrastructure in the run-up to a hugely important event. In other words, it's the government that hates you. Don't worry, they hate us too.
Are you looking at the clothes? Eva Longoria Parker stripped off as she posed with husband Tony to advertise the London Fog fashion line. Eva Longoria Parker s
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
The role of biosensors in the detection of emerging infectious diseases
Ronaldo's monster pay-packet was the result of his eye-watering pound 38.5 million-a-year salary with Spanish giants Real Madrid and endorsement deals with the likes of Nike, watchmaker Tag Heuer and nutrition supplements group Herbalife - themselves worth pound 22 million.
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Bryant is the first player this season with four or fewer points on 14 or more field goal attempts.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Comic skit “I Want To Be In Spring Festival Gala” (Various artistes)
《小镇疑云》，BBC America，3月4日播出。大卫·田纳特(David Tennant)携第二季归来，在这部引人共鸣的英国推理剧中继续饰演亚力克·哈迪(Alec Hardy)探员（去年他在美国翻拍版的《小镇疑云》[Gracepoint]中饰演埃米特·卡弗探员）。这部剧将于周一在英国首映，制作人们已经开始谈起第二季的秘密情节了，编剧克里斯·齐布纳尔(Chris Chibnall)在接受英国杂志采访时说的话可能会让剧迷不爱听，“第二季不是讲罪案的。”奥莉薇娅·科尔曼(Olivia Colman)继续饰演艾丽·米勒(Ellie Miller)探员，夏洛特·兰普林(Charlotte Rampling)和玛丽安娜·琼-巴普迪斯特(Marianne Jean-Baptiste)也加入了演员阵容。
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
11. Another 26 Favorites — because why not? Many of these could have made my top 10 on another day. “’71,” “Amy,” “Anomalisa,” “Blackhat,” “Chi-Raq,” “Ex Machina,” “Experimenter,” “Gett: The Trial of Viviane Amsalem,” “The Good Dinosaur,” “The Great Man,” “Inside Out,” “Joy,” “Lost Landscapes of Los Angeles,” “Magic Mike XXL,” “Office,” “Results,” “The Revenant,” “Seymour: An Introduction,” “Shaun the Sheep Movie,” “Spy,” “Straight Outta Compton,” “Tangerine,” “Timbuktu,” “Trainwreck,” “White God” and “The Wolfpack.”
Inhibition of SARS coronavirus helicase by bismuth complexes
Premiered on Jan 29, the drama received 7 points out of 10 on the country's popular review website Douban.
It is also reported that Chinese citizens made 1.26 billion cinema visits in 2015, a roughly 51 percent increase from a year earlier.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Lana Del Rey, 'Lust for Life'
Intel welcomes its new employees to the company by rolling out the red carpet -- literally -- once a quarter. During the first day of orientation, hires walk along a pathway lined with Intel Studios' photographers and videographers before introducing themselves onstage and receiving their welcome packages (and a round of applause from an audience of new colleagues).
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Haub School of Business at Saint Joseph’s University in Pennsylvania is the only school ranked for the first time, in 98th place.
The film is shot to mark the tenth anniversary of the television series, first released in 2005.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
brace原指双臂，用双臂支撑－使稳固用两个brace embrace（v 拥抱）
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
This elegant, informative and borderline beautiful sentence is a reminder that despite the horrific nature of the entries below, clarity remains attainable.
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
If you’re looking for a free CRM system, Zoho is probably the one for you. Why? It comes down to the integration possibilities. For example, Zoho integrates with JotForm and Unbounce simply by adding your API key. This means that within seconds, web leads will automatically be sent to your CRM. Pretty powerful for being free.
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Seven schools made it back into the top 100 after having missed out in the past year or two.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
‘Law & Order: SVU’ This NBC ripped-from-the-soap-opera perils of Olivia (Mariska Hargitay) — psychopath rapist-stalker, tortured love affair, new baby — that took up so much air last season finally died down, and this season, the show’s 16th, the detectives got back to sex crimes à clef, including a Ray Rice-inspired episode about a star sportscaster who was seen on a surveillance camera punching the lights out of his wife.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Airlines with operations based west of the Rockies boast the fewest flights that arrive late during the holidays, according to data compiled for Forbes.com by FlightAware.
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
“Lotte will hurt the Chinese people and the consequences could be severe,” said the report, which followed a string of government probes into the company’s business interests in China.
“与前些年相比，今年两会适逢领导人换届，还将讨论机构改革。会上还将讨论贯彻执行十八大政策的详细规划。”Lee Kyu-hyung, Republic of Korea ambassador
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
James Bond Themes 1. "Goldfinger" by Shirley Bassey
We have confidence that we will continue to open this country at a higher level, and maintain this country as a popular destination for investment. We welcome other partners to work with us to share in the development opportunities of China.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Morocco is a gateway to Africa. Major tourism cities in the North African kingdom include the capital of Rabat, Casablanca – the country's largest city - Marrakesh and Agadir.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
To be sure, that excitement can certainly lead to unrealistic declarations from those in the community. Some bitcoin developers and investors proclaim that within five years, all the major banks will be accepting bitcoin. That’s a stretch, acknowledges Peter Smith, COO of the bitcoin wallet Blockchain (not to be confused with the actual bitcoin block chain). “I hear a lot of predictions about how soon the whole world will be using bitcoin, and most of the time, those are unrealistic,” he says. “What we’re trying to do as an ecosystem is incredibly audacious, so it’s going to take a lot of time.”
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
A modular microarray imaging system for highly specific COVID-19 antibody testing
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
The Fate of the Furious was the top-grossing foreign film, ranking second on the list.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
The central bank last year spent more than six months signaling its intent to wean the economy off a third round of bond-buying, and the prospect upset markets at just about every turn. Now it's only in the first stage of that process.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Embrace the world
7. Hearing Aid
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
The seven large brick tombs were likelyconstructed for people of wealth, the researchers said.
The other tweet was published on Inauguration Day, and Obama said, "It's been the honor of my life to serve you. You made me a better leader and a better man."
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
“We need to do what the mayor wants everybody to do, and that is build more housing,” said Steven Spinola, the president of the Real Estate Board of New York. However, “if the numbers don’t work, if the rent that is coming in is less than the cost of maintaining the building, then you are not going to do it.”
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
His first coding effort resulted in an app that played audio snippets from speeches by his idol, Steve Jobs, whose unauthorized biography he'd recently devoured. 'It was rejected by Apple for every reason,' D'Aloisio says now, laughing. 'Copyrighted audio, poor functionality, too simple.' Another early design allowed users to touch a picture of wood, producing a knocking sound. A third transformed a smartphone screen into a treadmill for your fingers. That one earned about $120 in sales on its first day.
Anti-HIV drug repurposing against SARS-CoV-2
11. “The Black Panthers: Vanguard of the Revolution” (Stanley Nelson)
Length-scale dependence of protein hydration-shell density
This post is in partnership with Time. The article below was originally published at Time.com
Fiddle with items, your hair, flick your fingers, rub your leg, pace, rock, and bite your lips.(Well, most of that could just be on the "how to cumberbatch" list)
“Policymakers around the world are cognisant of the impact the Fed decision will have and are worried, which makes us worried,” said Simon Lue-Fong, head of global emerging debt at Pictet Asset Management. “People are saying the decision is priced in but seeing as no one knows exactly what will happen how can that possibly be true.”
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
“An employee bragged to all his colleagues that it was his last day, but failed to let his boss or the HR manager know.”
While not a low rating when compared to the other four dramas, it was still criticized by many audience members.
About this collection
In a televised debate on Monday night, Mr Wilders called on the Netherlands to expel the Turkish ambassador.
“The Man Who Knew is an impressive work of scholarship,” Lionel Barber, editor of the FT and chair of the book award judges, said. “It’s a masterpiece of political economy and, above all, it’s a great and enjoyable read.”